Q: Which are the major differences between NIOX® and NIOX Flex?
A: New faster PC with Microsoft Windows XP operating system. Two USB ports for convenient data transfer. Upgraded NIOX Software - including: new faster database, improved database handling with sophisticated data export function etc. A system prepared for the new additional research kit, NIOX Flex FlexFlow.
Q: Are there any centers where NIOX Flex is used in clinical practice?
A: NIOX (the precursor to NIOX Flex) is used for routine clinical practice at many centers throughout USA, Europe and Asia. For your nearest site, please send a request via email or call 866-ASK-NIOX.
Q: How does NIOX Flex exclude interference from nasal NO levels?
A: Closing the velum during exhalation eliminates the potential risk of contamination from nasal NO. If the velum is not closed, the exhalation measurement is not accepted as valid by the NIOX Software, and must be repeated.
Q: Can I do offline measurements with NIOX Flex?
A: Yes, you may order NIOX Flex Offline software, a NIOX Flex research application to determine the concentration of nitric oxide in gas collected in sampling bags.
Q: Can I do tidal breath measurements with NIOX Flex?
A: We have a prototype research kit available, intended for investigational use only. Please contact your local Aerocrine representative or Aerocrine directly for more information email.
Q: Can NIOX Flex be used for nasal NO measurements?
A: Yes, NIOX Flex Nasal, a research application intended for investigational use, is available. NIOX Flex Nasal is an application used to determine the concentration of nitric oxide in gas aspirated from one nostril, using passive sampling at a flow rate of 5 ml/sec.
Q: How has NIOX Flex been tested?
A: NIOX Flex has been verified in comprehensive test programs. The reproducibility and repeatability of NIOX measurements have been studied in GCP clinical studies and have been found to be excellent with a mean pooled standard deviation of 2.1 ppb (3).
Q: How accurate are measurements above the calibration curve 200 ppb?
A: The device is calibrated between 0 and 200 ppb for exhaled NO measurements.
In this range the accuracy is
± 2.5 ppb or 5 % (at 200 ppb). In the range 200–300 ppb the accuracy is similar to that at the 200 ppb level.
Q: How often do you need to calibrate the instrument? Who is qualified to do it?
A: The instrument should be calibrated every two weeks, or whenever it is restarted. The product offer includes a mandatory training session. Everyone who completes the training is skilled to do the calibration. Self test ensures system drift is <3 ppb between calibrations.
Q: Is the calibration gas included?
A: A unique NIOX calibration gas from AGA Linde Gas is included in the first shipment (200 ppb NO in N2, with a shelf life of 9 months from delivery). Additional NIOX calibration gas can be ordered from Aerocrine or another gas supplier of your choice provided the gas meets the NIOX calibration gas requirement specification.
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