A range of research applications are available for your NIOX Flex device. The research kits allow you to broaden the use of NIOX Flex with other applications in addition to single breath on-line measurements according to the ATS/ERS guidelines. Refer to the annually updated Scientific Backgrounder, published by Aerocrine for a review ofthe present literature.
NIOX Flex Nasal
Nasal Nitric Oxide (NO) can be measured with the CE-marked NIOX Flex Nasal application, giving repeatable and reproducible results (5).
NIOX Flex Nasal enables passive sampling from one nostril (NIOX Flex samples the gas at a flow rate of ~5 ml/sec). The NIOX Flex Nasal application comes with a recommended, although not standardized, sampling method.
Nasal NO measurement is in an exploratory phase with different techniques used by various centers. It is too early today to state which technique is superior to another.
The references can be obtained through your local Aerocrine representative. Ordering information
NIOX Flex Offline
NIOX Flex Offline is a research application, which enabels you to analyze samples collected in bags.
The start kit comprises an adaptor to enable connection to NIOX Offline Filter and your own bags with a luer lock fitting.
Ordering information
NIOX Flex FlexFlow
With the FlexFlow research kit, specifically developed to be used in conjunction with NIOX Flex, you will be receiving a useful tool for research purposes when investigating the location of airway inflammation.
NIOX Flex FlexFlow, enables you to measure exhaled NO at different flow rates in NIOX Flex with a plug-in electronic flow regulator valve. Software-controlled flow levels range between 10 and 330 ml/sec. The software application includes preset test settings (i.e. measurement length, number of repeated measurements etc.) for a number of flows which can be modified. It also features improved measurement control, data analysis and calculations.
A simple formula will calculate Slope and Intercept values in a graph presented in the interface - NO-output vis-à-vis exhaled flow. A regression analysis measures the quality of the measurements. A new measurement at a specific flow can be taken to add missing points on the curve.
The Slope-Intercept values calculated can be used to learn more about the peripheral inflammation in a patient – alveolar NO concentration and the bronchial NO flux - the Flow-Independent Parameters (FIP) (6) (7).
Flow-independent NO measurement is still in an exploratory phase with different algorithms used by various centers. It is too early today to state which technique is superior to another and to state normal values. Ordering information
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