For the technology underlying NIOX® Flex, Aerocrine AB holds a comprehensive patent portfolio in prioritized markets:
US Patent 5,447,165
US patent 5,922,610
US patent 6,038,913
US patent 6,063,027
US patent 6,099,480
US patent 6,149,606
US patent 6,183,416
US patent 6,511,425
US patent 6,626,844
US patent 6,723,056
US patent 6,761,185
and other patents pending.
NIOX® is a registered trademark by Aerocrine AB.
NO-free air (scrubbed inhalation air)
eliminates contamination from high
ambient NO levels, as stated in the ATS/ERS guidelines.
Minimized instrument dead space,
<10 ml, resulting from placement of
sampling port very close to the mouth,
together with vacuum in sampling tube
and NIOX Filter, give reliable and accurate results.
Deadspace is modifiable and can be
regulated by exhalation time (fractions
of a second), by exhalation volume (ml)
or by a calculated volume (ml) based on
patient's height. Deadspace
is exhaled unrestricted, without flow
regulation.
Unique NIOX Flow Control keeps
exhalation at 50 ml/sec regardless
of patient skill. Easy for even young
patients to comply with. An elastic
membrane valve mechanically adjusts
flow rate. This ensures reproducible values with very small variatons.
NO Plateau. FENO value is calculated by
creating an NO plateau for at least 3 seconds.
Exhalation is set to 10 seconds, NO
plateau set to between 70–100% of the
exhalation (between 7 and 10 sec). The
settings can be adjusted.
Chemiluminescence. NIOX Flex uses the high sensitivity
and high specificity of a chemiluminescence gas analyzer, the most accurate method available for measuring NO molecules at very low concentrations.
Automatic Self Test between patient measurements validates the calibration and detects any zero-point drift in order to ensure that every FENO value is accurate and reproducible.
Default Test Settings ensure that collected measurements comply with ATS/ERS guidelines and that the exhalation quality is assured.
Automatic Maintenance Guide. A reminder indicates when to perform system maintenance and change calibration gas.
Infrequent Calibration. 14 days between calibrations.
USB ports to facilitate data management and print functions.
Comprehensive patient reports including measurement results with FENO, VNO, Pressure and Flow graphs.
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